CovidChloroV1, Main, Exploration, bibRecord, 000027

[Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients].

Identifieur interne : 000027 ( Main/Exploration ); précédent : 000026; suivant : 000028

[Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients].

Auteurs : S. Ortonobes Roig [Espagne] ; N. Soler-Blanco ; I. Torrente Jiménez ; E. Van Den Eynde Otero ; M. Moreno-Ari O ; M. G Mez-Valent

Source :

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia [ 1988-9518 ] ; 2021.

RBID : pubmed:33522213

Descripteurs français

English descriptors

KwdEn :
- Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), COVID-19 (blood), COVID-19 (drug therapy), COVID-19 (mortality), Chloroquine (therapeutic use), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Male (MeSH), Physical Functional Performance (MeSH), Polypharmacy (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Treatment Outcome (MeSH).
MESH :
- chemical , therapeutic use : Antiviral Agents, Azithromycin, Chloroquine, Hydroxychloroquine.
- blood : COVID-19.
- drug therapy : COVID-19.
- mortality : COVID-19.
- Aged, 80 and over, Female, Hospitalization, Humans, Male, Physical Functional Performance, Polypharmacy, Retrospective Studies, Risk Factors, Treatment Outcome.

Abstract

OBJECTIVE

Despite the impact of SARS-CoV-2 infection in geriatrics, data on nonagenarian patients is scarce. The aim of this study is to describe the clinical features of COVID19-diagnosed nonagenarians, as well as its clinical evolution and therapeutic response.

METHODS

Retrospective observational study of nonagenarians, admitted for COVID-19. Sociodemographic and clinical variables were registered, including previous polypharmacy. Blood analysis data and COVID-19-specific treatment were registered.

RESULTS

A total of 79 patients were included, with 50.6% (40 patients) of mortality. None of the comorbidities registered correlated with mortality, which was significantly higher among patients with moderate/complete functional dependence, compared to those mild-dependents/independents (59.5% vs 40.5%; p=0.015). Most prescribed drugs were hydroxychloroquine/chloroquine and azithromycin. Non-survivors presented higher counts of leukocytes and neutrophils, and higher lymphopenia.

CONCLUSIONS

Nonagenarians with functional dependence presented higher mortality, irrespective of comorbidities or treatment received. Implementing an integral geriatric evaluation would enhance the implementation of personalized therapeutic strategies for nonagenarians.

DOI: 10.37201/req/130.2020
PubMed: 33522213
PubMed Central: PMC8019469

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000411
to stream Main, to step Curation: 000411

Le document en format XML

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<term>COVID-19 (blood)</term>
<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (mortality)</term>
<term>Chloroquine (therapeutic use)</term>
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<term>Hospitalization (MeSH)</term>
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<term>Hydroxychloroquine (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Physical Functional Performance (MeSH)</term>
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<term>Retrospective Studies (MeSH)</term>
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<term>Treatment Outcome (MeSH)</term>
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<term>Chloroquine (usage thérapeutique)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Mâle (MeSH)</term>
<term>Performance fonctionnelle physique (MeSH)</term>
<term>Polypharmacie (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
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<term>Performance fonctionnelle physique</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
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<p>Despite the impact of SARS-CoV-2 infection in geriatrics, data on nonagenarian patients is scarce. The aim of this study is to describe the clinical features of COVID19-diagnosed nonagenarians, as well as its clinical evolution and therapeutic response.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Retrospective observational study of nonagenarians, admitted for COVID-19. Sociodemographic and clinical variables were registered, including previous polypharmacy. Blood analysis data and COVID-19-specific treatment were registered.</p>
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<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>A total of 79 patients were included, with 50.6% (40 patients) of mortality. None of the comorbidities registered correlated with mortality, which was significantly higher among patients with moderate/complete functional dependence, compared to those mild-dependents/independents (59.5% vs 40.5%; p=0.015). Most prescribed drugs were hydroxychloroquine/chloroquine and azithromycin. Non-survivors presented higher counts of leukocytes and neutrophils, and higher lymphopenia.</p>
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<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Nonagenarians with functional dependence presented higher mortality, irrespective of comorbidities or treatment received. Implementing an integral geriatric evaluation would enhance the implementation of personalized therapeutic strategies for nonagenarians.</p>
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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000027 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000027 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidChloroV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:33522213
   |texte=   [Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients].
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:33522213" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidChloroV1

This area was generated with Dilib version V0.6.38.
Data generation: Sat May 22 17:02:32 2021. Site generation: Sat May 22 17:06:52 2021

	Serveur d'exploration COVID et hydrochloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration COVID et hydrochloroquine

[Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients].

[Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki